Articles in International Journals

1)   Cannataro M, Weber dos Santos R, Sundnes J: Biomedical and Bioinformatics Challenges to Computer Science: Bioinformatics, Modeling of Biomedical Systems and Clinical Applications, Procedia Computer Science, pp. 1058-1061Volume 4, 2011, ISSN: 1877-0509

2) Edvardsen T: Can modern echocardiographic techniques predict drug induced cardiotoxicity? (Editorial) J Am Coll Cardiol, pp. 2271-227257, (22), 2011, Print ISSN 0735-1097 – Online ISSN 1558-3597

3)  Edvardsen T, Haugaa KH: Imaging assessment of ventricular mechanics. Heart, pp. 1349-56, 97(16), 2011, ISSN: 1355-6037

4)   Eek C, Grenne B, Brunvand H, Aakhus S, Endresen K, Smiseth OA, Edvardsen T, Skulstad H: Post systolic shortening is a strong predictor of viability in patients with non ST-elevation myocardial infarction Eur J Echocardiography, pp. 483-91, 2(7), 2011, Online ISSN 1532-2114 - Print ISSN 1525-2167

5)   Gjesdal O, Remme EW, Opdahl A, Skulstad H, Russell K, Kongsgaard E, Edvardsen T, Smiseth OA: Mechanisms of Abnormal Systolic Motion of the Interventricular Septum during Left Bundle-Branch Block Circulation: Cardiovasc Imaging, pp. 264-734,(3), 2011, Print ISSN: 1941-965 - Online ISSN: 1942-0080

6)   Goebel B, Gjesdal O, Kottke D, Otto S, Jung C, Lauten A, Figulla, HR, Edvardsen T, Poerner TC: Myocardial function in patients with isolated hypertensive heart disease: a two dimensional ultrasound speckle tracking study. J Hypertension, pp. 2255-64, 29(11), 2011, ISSN: 0263-6352 Online ISSN: 1473-5598

7)   Grenne B, Eek C, Sjøli B, Dahlslett T, Hol PK, Ørn S, Skulstad H, Smiseth OA, Edvardsen T, Brunvand H: Mean Strain Throughout the Heart Cycle by Longitudinal Two-Dimensional Speckle-Tracking Echocardiography Enables Early Prediction of Infarct Size J Am Soc Echocardiogr, pp. 1118-25, 24(10), 2011, ISSN: 0894-7317

8)   Hanslien, M, Artebrant, R., Tveito, A., Lines, GT and Cai, X. Stability of two time-integrators for the Aliev-Panfilov system, International Journal of Numerical Analysis and Modeling 8(3): 427-442, 2011.

9)  Haugaa KH, Edvardsen T, Amlie JP. Prediction of Life-Threatening Arrhythmias - Still an Unresolved Problem. Cardiology. pp. 129-137, 118(2), 2011, Print ISSN 0008-6312  -  Online e-ISSN 1421-9751

10)   Haugaa KH, Bergestuen DS, Sahakyan L, Skulstad H, Aakhus S, Thiis-Evensen E, Edvardsen T: Evaluation of Right Ventricular Dysfunction by Myocardial Strain Echocardiography in Patients with Intestinal Carcinoid Disease. J Am Soc Echocardiogr. 644-50, 24(6), 2011, ISSN: 0894-7317

11)   Hopp E, Lunde K, Solheim S, Aakhus S, Edvardsen T, Smith HJ: Regional myocardial function after intracoronary bone marrow cell injection in reperfused anterior wall infarction – a tagging MR study. J Cardiovasc Magnetic Res,13:22, 2011, ISSN: 1532-429X

12)   McDowell K, Arevalo H, Maleckar MM, Trayanova N: Susceptibility to reentry in the infarcted heart depends on the active fibroblast density, Biophysical Journal 110(6):1307-15, 2011.

13)   Nagueh SF, Bhatt R, Vivo RP, Krim SR, Sarvari SI, Russell K, Edvardsen T, Smiseth OA, Estep JD: Echocardiographic Evaluation of Hemodynamics in Patients with Decompensated Systolic Heart Failure Circulation: Cardiovasc Imaging, pp.  220-74, (3), 2011, Print ISSN: 1941-9651 - Online ISSN: 1942-0080

14)   Niederer SA, Kerfoot E, Benson A, Bernabeu MO, Bernus O, Bradley C, Cherry EM, Clayton R, Fenton FH, Garny A, Heidenreich E, Land S, Maleckar M, Pathmanathan P, Plank G, Rodríguez JF, Roy I, Sachse FB, Seemann G, Skavhaug O  and Smith NP. N-Version Benchmark Evaluation of Cardiac Tissue Electrophysiology Simulators. Philosophical Transactions of the Royal Society VPH Special Issue. Philos Transact A Math Phys Eng Sci. pp. 4331-5, 1369(1954), 2011, (online) ISSN 1471-2962

15)   Odland HH, Brun H, Sejersted Y, Dalen M, Edvardsen T, Saugstad OD, Thaulow E: Longitudinal Myocardial Contribution to Peak Systolic Flow and Stroke Volume in the Neonatal Piglet Heart Pediatric Research Pediatr Res.pp. 345-570,(4), 2011, ISSN: 0031-3998 - Online ISSN: 1530-0447

16)   Remme EW, Opdahl A, Smiseth OA. Mechanics of left ventricular relaxation, early diastolic lengthening and suction investigated in a mathematical model. American Journal of Physiology, 300:H1678-87, 2011, Print ISSN: 0363-6135 Online ISSN: 1522-1539

17)   Røsjø H, Andreassen J, Edvardsen T, Omland T: Prognostic Usefulness of Circulating High Sensitivity Troponin T in Aortic Stenosis and Relation to Echocardiographic Indices of Cardiac Function and Anatomy. Am J Cardiol pp.88-91, 108(1), 2011, ISSN: 0002-9149

18)   Sarvari SI, Haugaa KH, Anfinsen OG, Smiseth OA, Amlie JP, Edvardsen T: Right Ventricular Mechanical Dispersion Predicts Malignant Arrhythmias in Patients With Arrhythmogenic Right Ventricular Cardiomyopathy. Eur Heart J, pp. 1089-1096, 32(9), 2011, Online ISSN 1522-9645 - Print ISSN 0195-668x

19)   Sjøli B, Grenne B, Smiseth OA, Edvardsen T, Brunvand H: The Advantage of Global Strain compared to Left Ventricular Ejection Fraction to predict Outcome after Acute Myocardial Infarction. Echocardiography, pp. 556-63, 28(5), 2011, ISSN: 0742-2822

20)   Smedsrud MK, Pettersen E, Gjesdal O, Svennevig JL, Andersen K, Ihlen H, Edvardsen T: Detection of Left Ventricular Dysfunction by Global Longitudinal Systolic Strain in Patients with Chronic Aortic Regurgitation J Am Soc Echocardiogr, 1253-9, 24(11), 2011, ISSN: 0894-7317

21)   Snare SR, Mjølstad OC, Orderud F, Haugen BO, Torp H.,"Fast automatic measurement of mitral annulus excursion using a pocket-sized ultrasound system.", Ultrasound Med Biol.; pp. 617-31, 37(4), 2011, ISSN: 0301-5629

22)   Tsai HR, Gjesdal O, Wethal T, Haugaa KH, Fosså A, Fosså SD, Edvardsen T. Left Ventricular Function Assessed by Two-Dimensional Speckle Tracking Echocardiography in Long-Term Survivors of Hodgkin's Lymphoma Treated by Mediastinal Radiotherapy With or Without Anthracycline Therapy. Am J Cardiol., pp. 472-7, 107(3), 2011, ISSN: 0002-9149

23)   Tveito A, Lines GT, Artebrant R, Skavhaug O, Maleckar MM:Existence of excitation waves for a collection of cardiomyocytes electrically coupled to fibroblasts, Mathematical Biosciences(230(2)):79-86, 2011.

24)   Tveito A, Lines GT, Li P, and McCulloch A. On Defining candidate drug characteristics for Long-QT, Mathematical Biosciences and Engineering 8(3):861-873, 2011.

25)   Tveito A, Lines GT, Rognes ME, and Maleckar MM. An analysis of the shock strength needed to achieve defibrillation in a simplified mathematical model of cardiac tissue, Accepted for publication in International Journal of Numerical Analysis and Modeling, 2011.

26)   Tveito A, Lines GT, Skavhaug O, and Maleckar MM. Unstable eigenmodes as possible drivers for cardiac arrhythmias, Journal of the Royal Society Interface 8(61):1212-6, 2011

27)   Tveito A, Skavhaug O, Lines GT, and Artebrant R. Computing the stability of steady-state solutions of mathematical models of the electrical activity in the heart, Mathematical Biosciences and Engineering 41(8):611-618, 2011.

28)   Wall S, Guccione J, Ratcliffe M, and Sundnes J. Electromechanical feedback in the presence of reduced conduction alters electrical activity in an infarct injured left ventricle – a finite model study, Submitted to American Journal of Physiology - Heart and Circulatory Physiology, 2011.

29)   Wyller VB, Aaberge L, Thaulow E, Døhlen G.  Percutaneous catheter-based implantation of artificial pulmonary valves in patients with congenital heart defects. Tidsskr Nor Laegeforen. pp 1289-93, 131(13-14). Norwegian, 2011. [Article in Norwegian] Print ISSN 0029-2001 – Online ISSN 0807-7096

30)   Wyller VB, Thaulow E, Aaberge L, Døhlen G. Evidence-based materials and independent physicians. Tidsskr Nor Laegeforen. Sep 6;131(17):1637, 2011, [Article in Norwegian] Print ISSN 0029-2001 – Online ISSN 0807-7096

31)   Aarones M, Gullestad L, Aakhus S, Ueland T, Skaardal R, Aass H, Wergeland R, Smith HJ, Aukrust P, Kongsgaard E: Prognostic value of cardiac troponin T in patients with moderate to severe heart failure scheduled for cardiac resynchronization therapy. Am Heart J, pp. 1031-7, 161 (6) , 2011, ISSN: 0002-8703

32)   Aase SA, Snare SR, Dalen H, Støylen A, Orderud F, Torp H., "Echocardiography without electrocardiogram.", Eur J Echocardiogr.; pp. 3-10, 12(1), 2011, Online ISSN 1532-2114 - Print ISSN 1525-2167

Books/Chapters in Books

1)   Gjesdal O and Edvardsen T: Tissue Doppler in Ischemic Heart Disease. Doppler Echocardiography. In Establishing Better Standards of Care in Doppler Echocardiography, Computed Tomography and Nuclear Cardiology, Edited by: Richard M. Fleming, In-Tech 2011, ISBN 978-953-307-366-8

2) Haugaa KH, Amlie JP, Edvardsen T: Prediction of Ventricular Arrhythmias in Patients at Risk of Sudden Cardiac Death. In Cardiac defibrillation – prediction, prevention and management of cardiocascular arrhythmic events, Edited by: Joyelle J. Harris,  In-Tech 2011,  ISBN 978-953-307-692-8


Dissemination of results to users: Presentations and abstracts

1) Edvardsen, T., Mechanical consequences of ion channel dysfunction. AHA Scientific sessions 11. Orlando, US. November 15th, 2011.

2) Edvardsen T., How to predict malignant arrhythmias by strain echocardiography. XV1th World Congress of Cardiology & Echo: Sept 30th-Oct 2nd, 2011, Delhi NCR. India.

3)   Edvardsen T., Are All Measurements Created Equal? How Do We Compare Various Methods and Platforms? 22nd Annual meeting. American Society of Echocardiography. June 11-14th 2011, Montreal, Canada.

4)   Edvardsen T., Informative use of echocardiography in patients with non-ST-elevation myocardial infarction. Pre session meeting, ACC 60th Annual Scientific sessions. April 2011, Chicago, US.

5)   Edvardsen, T., The future for echocardiography. Oct 2011. The 25th national meeting in echocardiography. Org: Norwegian Society of Cardiology.

6) Edvardsen, T., Research at Dept of Cardiology, OUS, Rikshospitalet. Nov 22nd, 2011. Norwegian PhD conference in Medical Imaging.

7)   Maleckar, M. "Right through the heart: biophysically-based strategies for modelling cells and tissues." Computational Life Sciences Seminar Series. Given at Ole Johans Dahls Hus, UiO Department of Informatics, Faculty of Mathematics and Natural Sciences. 01.06.2011.

8)  Russell K, Work shop in arrhythmia. Electrical Dyssynchrony and Regional Myocardial Work, Oslo University Hospital, Ullevål June 9th, 2011.

9)   Sundnes, J. "Electro-Mechanics of the Infarct Injured Heart", International conference on numerical analysis and applied mathematics, September 2011, Greece.

10)   Sundnes, J. "Strongly Coupled Electro-Mechanics", presented at the University of Basel, Switzerland, June 2011.

11) Sundnes, J. "Strongly Coupled Electro-Mechanics Simulations of the Infarct Injured Heart", presented at the Federal University of Juiz de Fora, Brazil, January 2011.

12)   Wall, S. "Multi-scale modeling of the heart - Computational approaches and applications to biomedicine".  Scientific Computing and Imaging Institute, University of Utah, July 13th, 2011.

13)   Wall S, Sundnes J, Gurev G, Kerkhoffs R, and Prot V.  "Modeling coupled electro-mechanics in the Heart". Minisymposium at SIAM CSE '11, February 28-March 4th 2011, Reno, NV, USA.

14)   Aaberge, L., "Koronarsykdom og hjertesvikt, Trondheim" oktober 11, obligatorisk kurs for kardiologispesialiteten, 2011

15)   Aaberge, L., Kardiogent sjokk og mekaniske komplikasjoner etter hjerteinfarkt,  11.10.2011

16)   Aaberge, L., Kirurgisk behandling ved hjertesvikt? 12.10. 2011

17)   Aaberge, L., Akutt koronarsyndrom - klinikk og akuttbehandling. CardioVascular Update 14.10.11

18)   Aaberge, L., Helsedirektoratet 04.06.2011: Hvilke endringer kan vi forvente oss innen kardiologien de neste 10 år.

19)   E. Boe, K. Russell, E W. Remme, O. Gjesdal, O A. Smiseth, H. Skulstad, Poster: Detrimental effect of biventricular and left ventricular pacing in acute heart failure with narrow QRS and mechanical dyssynchrony. ESC Congress Paris, August  27-31st, 2011

20)   Broch K, Eek C, Wergeland R, Ueland T, Skårdal R, Aukrust P, Skulstad H, Gullestad L. N-terminal pro-B-type natriuretic peptide is a marker of reversible myocardial dysfunction after non-ST-elevation acute coronary syndrom. Heart failure 2011. P1314.

21)   M. Cannataro, R. W. dos Santos and J Sundnes. Biomedical and Bioinformatics Challenges to Computer Science: Bioinformatics, Modeling of Biomedical Systems and Clinical Applications, Workshop at International Conference on Computational Science, June 2011.

22)   T Dahlslett, B Grenne, C Eek, B Sjøli, H Skulstad, OA Smiseth, T Edvardsen, H Brunvand: Early Strain Echocardiography May Exclude Significant Coronary Artery Stenosis in Suspected Non-ST-Elevation Acute Coronary Syndrome. Circulation, Nov 2011; 124: A11678, Print ISSN: 0009-7322 - Online ISSN: 1524-4539

23)   B. Goebel, K. Haugaa, K. Meyer, A. Lauten, C. Jung, S. Otto, H.R. Figulla, T. Edvardsen, T.C. Poerner : Remodelling of left ventricular mechanic in dilated cardiomyopathy: a two-dimensional speckle tracking echocardiography study. European Heart Journal ( 2011 ) 32 (Abstract Supplement ), 779, Online ISSN 1522-9645 - Print ISSN 0195-668x

24)   Grenne B, Eek C, Sjøli B, Dahlslett T, Hol PK, Ørn S, Skulstad H, Smiseth OA, Edvardsen T, Brunvand H. H The area under strain curve provides early prediction of infarct size in patients with acute myocardial infarction. J Am Coll Cardiol. 2011(abstract supplement, Page E718)

25)   K.H. Haugaa, B. Goebel, T. Dahlslett, K. Meyer, C. Jung, A. Lauten, H.R. Figulla, T. Poerner, T. Edvardsen. Risk of ventricular arrhythmias in patients with idiopathic dilated cardiomyopathy can be identified by left ventricular global strain. European Heart Journal ( 2011 ) 32 ( Abstract Supplement ), 11-12, Online ISSN 1522-9645 - Print ISSN 0195-668x

26)   Haugaa KH, Grenne BL, Voigt JU, Florian A, Sjøli B, Brunvand H, Eek CH, Desmet W, Svendsen JH, Smiseth OA, Edvardsen T. Global Strain by Echocardiography is Superior to Ejection Fraction to Predict Ventricular Arrhythmias After Myocardial Infarction. Circulation 2011, Nov 2011; 124: A15136, Print ISSN: 0009-7322 - Online ISSN: 1524-4539

27)   Haugaa KH, Grenne BL, Voigt JU, Florian A, Sjøli B, Brunvand H, Eek CH, Desmet W, Svendsen JH, Smiseth OA, Edvardsen T. Mechanical Dispersion Predicts Ventricular Arrhythmias After Myocardial Infarction.  Circulation 2011, Nov 2011; 124: A11932., Print ISSN: 0009-7322 - Online ISSN: 1524-4539

28)   Helland IB, Dahlslett T, Skulstad H, Rasmussen M, Knardal S. Neuronal Ceroid Lipofuscinosis in Norway. EPNS, Nov 2-5th, Hannover Germany, 2011. Journal of Pediatric Neurology vol:15/S1 (2011) S49

29)  TM Helle-Valle, HJ Smith, E Hopp, Kl Lunde, T Vartdal, O Gjesdal, T Edvardsen, OA Smiseth: Transmural Infarct Distribution in Reperfused Myocardium after STEMI. Circulation, Nov 2011; 124: A15006, Print ISSN: 0009-7322 - Online ISSN: 1524-4539

30)   Hetland A, Haugaa KH, Olseng M, Gjesdal O, Ross S, Saberniak J, Jacobsen M , Edvardsen T Three months treatment with adaptive servo-ventilation improves cardiac function and  physical activity in patients with chronic heart failure and Cheyne-Stokes respiration in a prospective randomized controlled trial. Circulation 2011, Nov 2011; 124: A11007., Print ISSN: 0009-7322 - Online ISSN: 1524-4539

31)   Hyler S, Pischke SE, Halvorsen PS, Espinoza A, Bergsland J, Tonnessen TI, Fosse E, Skulstad H. Continuous Monitoring of Regional Function by a Miniaturized Ultrasound Sensor Allows Early Quantification of Low Grade Myocardial Ischemia. Circulation.  November 2011; A10254. (Abstract supplement)

32)   J. Koivumäki. Computational modeling of intracellular calcium dynamics in human atrial myocytes: impact on action potential morphology, Seminar at the Technical University of Dresden, Germany, 2011.

33)   J. Koivumäki. Excitation‐contraction coupling in human atrial myocytes: remodeling in atrial fibrillation,35th Meeting of the European Working Group on Cardiac Cellular Electrophysiology, 2011.

34)   J. Koivumäki. Rate-dependent regulation of sarcoplasmic reticulum Ca2+ ATPase in human atrial myocytes, The Scandinavian Physiological Society Annual Meeting, 2011.

35)   Maleckar MM. Modeling the effects of rotigaptide in atrial tissue: a cautionary tale. 9th International Conference of Numerical Analysis and Applied Mathematics, September 19-25, 2011.

36)   Remme EW. Mechanisms of characteristic features in measured deformation traces - replicated and explained in a finite element simulation model of the heart. Joint National Ph.D. Conference in Medical Imaging and MedViz Conference, January 17-18th, 2011.

37)   Remme EW, Niederer S, Gjesdal O, Russell K, Smith N, Smiseth OA. Abnormal septal motion in left bundle branch block - the effect of activation sequence, pressures and geometry. 4th Cardiac Physiome Conference, July 8-10th , 2011

38) K Russell, M Eriksen, L Aaberge, N Wilhelmsen, EW Remme, A Opdahl, KH Haugaa, T Edvardsen, OA Smiseth: Novel Method For Noninvasive Myocardial Work Analysis in Patients With Left Bundle Branch Block. Circulation, Nov 2011; 124: A12700., Print ISSN: 0009-7322 - Online ISSN: 1524-4539

39) K Russell, M Eriksen, L Aaberge, N Wilhelmsen, EW Remme, H Skulstad, O Gjesdahl, A Opdahl, E Kongsgaard, T Edvardsen, OA Smiseth: Wasted Work Fraction - A Novel Method For Assessing Dyssynchrony In Patients With Left Bundle Branch Block. Circulation, Nov 2011; 124: A14719, Print ISSN: 0009-7322 - Online ISSN: 1524-4539

40)   K. Russell,  E.W. Remme, O. Gjesdal, A. Opdahl, H. Skulstad, E. Kongsgaard, T. Edvardsen, O.A. Smiseth: Rate of LV pressure rise is an important confounder when assessing left ventricular electrical dyssynchrony by onset of myocardial shortening. European Heart Journal (2011 ) 32 ( Abstract Supplement ), 613, Online ISSN 1522-9645 - Print ISSN 0195-668x

41) S.I. Sarvari, O. Gjesdal, E. Gude, A. Satis, A.K. Andreassen, L. Gullestad, O. Geiran, T. Edvardsen: Predictors of one year mortality in heart transplant recipients. European Heart Journal ( 2011 ) 32 (Abstract Supplement ), 212-213, Online ISSN 1522-9645 - Print ISSN 0195-668x

42)   S. Wall. Modeling the infarct injured heart, insights into mechanical dysfunction, SIAM CSE Reno, Nevada, USA, 2011.

43)   S. Wall and J. Sundnes, organizers. Modeling coupled electromechanics in the cardiovascular system, Minisymposium at SIAM CSE '11, February 28-March 4th 2011, Reno, NV, USA.

44)   S. WallJ. Sundnes, N. Trayanova, R. C. P. Kerkhoffs, and V. Prot. Modeling coupled electromechanics in the cardiovascular system, SIAM CSE Reno, Nevada, USA, 2011


Dissemination of results to the general public: Popular science publications

1)   M. Maleckar. "The heart of the matter: Simula and the Center for Cardiological Innovation." Presented at a general meeting with representatives from the Norwegian Ministry of Trade and Industry, 14.04.2011.

2)   J. Sundnes. "Kan vi regne ut hvordan hjertet virker? Og hva kan vi i så fall bruke det til?". Presented at Idéfestivalen 2011, University of Oslo, September 17th, 2011.



1)   "Her skjer den heteste it-forskningen". Interview re: CCI, M. Maleckar. L.M. Kirknes. Computer World. 13.05.2011.

2)   "Nytt senter for kardiologisk innovasjon". Dagens Medisin, 31.10. 2011

4)   "Forsker med godt hjerte". South-Eastern Norway Regional Health Authority, 28.04. 2011

5)   Puls, Jakten på hjertets hemmelighet, Norwegian state television (NRK) Aug 2011

6)   "Nytt senter for forskningsdrevet innovasjon". Oslo University Hospital 02.11. 2011

Center for Cardiological Innovation