Sep 24, 2018

CHFR Symposium 2018



The Annual CHFR Symposium on Heart Failure has now been arranged for the 16th time. During these years the symposium has grown to become an international event, housing researchers from all around the world. The symposium covers a vast field within cardiology and cardiovascular diseases. This year young researchers presented data in the following sessions;

I: Biomarkers and cardiac disease
II: Cellular signaling: Myocardial hypertrophy and ischemia
III: Cardiac function during heart failure and exercise training
IV: Cellular signaling: Myocardial function and arrhythmias
V: Diagnostic and therapeutical strategies for cardiac disease
VI: Inflammatory mediators and metabolism

The center was well represented in the session for cardiac function during heart failure and exercise training, with almost half of the abstracts. Presenting were center PhD fellows John Aalen, MD, Ole Jakob Sletten, MD, Camilla Kjellstad Larsen, MD and Petter Storsten, MD.

Isotta Castrini, MD and Professor Sanjay Sharma, MD, PhD at Holmenkollen. Copyright: Kristina Haugaa


The winner of the best poster prize in this session was Isotta Castrini, MD, with her abstract “Effect of number of pregnancies on prognosis of women with arrhythmogenic cardiomyopathy”. The 2nd runner up was center PhD fellow Ole Jakob Sletten, MD.

Posted by: Anonymous

From the left: Associate professor Kasumi Masuda, MD, PhD, Professor Satoshi Nakatani, MD, PhD, Professor Otto Smiseth, MD, PhD, and Associate professor  Katsuji Inoue, MD, PhD.
Copyright: Kasumi Masuda


Among the invited speakers at the CHFR Symposium this year was the President of the Japanese Society of Echocardiography, Satoshi Nakatani from Osaka University Graduate School of Medicine. He held a very interesting talk on novel methods for quantification of left ventricular function.

International and national collaboration is important for the center and cooperation with cardiologists from Japan has been initiated. Visiting us this year has been Associate professor Kasumi Masuda, MD, PhD and Associate professor Katsuji Inoue, MD, PhD. They are both working on projects within the center work package that focuses on work efficiency and diastolic function, headed by Professor Otto Smiseth, MD, PhD.


Winner of the best poster prize


Castrini AI, Lie ØH, Leren IS, Estensen ME, Stokke MK, Klæboe L, Edvardsen T, Haugaa KH
Effect of number of pregnancies on prognosis of women with arrhythmogenic cardiomyopathy

Aims: We aimed to assess the relation between number of pregnancies and cardiac structure, function and arrhythmic events in women with arrhythmogenic cardiomyopathy (AC).

Methods and results: We included female AC-patients in a cross-sectional study. Number of pregnancies and pregnancy related arrhythmias were recorded. Ventricular arrhythmias were defined as aborted cardiac arrest, sustained ventricular tachycardia or appropriate implantable cardioverter defibrillator therapy. Right and left ventricular dimensions and function, including strain analyses, were assessed by echocardiography, and magnetic resonance imaging. We created a new AC severity score to grade the severity of AC disease. We included 77 women (age 47±16, 43 probands and 34 AC mutation positive female relatives), 19±14 years after last pregnancy. Median number of pregnancies was 2 (0-4); 19 had no previous pregnancies, 16 had 1 pregnancy, 30 had 22, and 12 had  ≥ 3 pregnancies. Presence of a definite AC diagnosis (p=0,36), severity of AC disease (p=0,53) and arrhythmic events (p=0,25) did not differ between groups of pregnancies. Number of pregnancies was related to increased right ventricular outflow tract diameter in single variable analyses (OR 1,76 (95%CI 1,08-2,87), p=0,02), but not when adjusted for body surface area and age (OR 1,56 (95%CI 0,91-2,66) p=0,11). The number of pregnancies was not associated with any other measure of cardiac structure and function.

Conclusion: High number of pregnancies did not seem to relate to a worse phenotype in women with AC.


Isotta Castrini, MD and Associate professor Kristina Haugaa, MD, PhD at Holmenkollen. Copyright: Kristina Haugaa

Center for Cardiological Innovation