Sep 16, 2016

ESC 2016



Each year the European Society of Cardiology organizes the largest cardiovascular congress in the world, with more than 30 000 participants. As always the Center for Cardiology was well represented with numerous posters and talks.

This year the meeting took place in Rome, Italy.

Unikard was also present, documenting the various research groups presenting at the congress, including the CCI.

Posted by: Anonymous

On the first day of the congress Center Director Professor Thor Edvardsen, MD, PhD chaired a symposium on cardio-oncology, looking into the connection between heart failure and the treatment of cancer.

Prof Edvardsen has excessive knowledge in the field of imaging and has for the past four years been Chair of the European Association of Cardiovascular Imaging (EACVI) Scientific Documents Committee, leading the work on European Guidelines for Cardiac Imaging.

The session was divided into four sections, starting with the latest news from EACVI’s COT-register, containing information on breast cancer patients from 19 different European countries.
One of the main purposes of the COT-register is to investigate and increase the awareness around the effects of cancer treatment, specifically breast cancer, in relation to cardiovascular diseases. The aim is to establish new guidelines for future treatment and early diagnosis. 

This section was followed up with the use of cardiac ultrasound and MR as a preventive measure to diagnose heart failure in patients without symptoms. The last two presentations focused on the need to screen patients suffering from cardiovascular diseases after radiation therapy and the use of a CT-scan of the heart as a tool for early diagnosis.


During the congress Center Director of Cardiology Research Kristina Hermann Haugaa, MD, PhD chaired in the Advances in science –session, topic being the prediction of sudden cardiac death.

The session introduced the current market leading imaging tools used in prediction of sudden cardiac death. Followed up by recent studies contributing to early diagnosis of heart failure and possible prevention of sudden cardiac death, ending the session with goals for future research.

Dr. Haugaa is one of the foremost experts in Norway in the field of genetic heart diseases that may cause life threatening ventricular arrhythmias and sudden cardiac death. She shed further light on the topic with her talk “Imaging of ARVC” under the symposium Imaging for early diagnosis of rare cardiomyopathies.

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a genetic heart muscle disease, predisposing to ventricular arrhythmias, heart failure and sudden cardiac death. The mechanism behind the disease is complex, affecting both electrical and mechanical properties of the heart, and involves dysfunction in the glue between the heart muscle cells. This condition ultimately leads to severe damage of the cardiac muscles. When the disease has advanced, it is fairly easy to differentiate it between other cardiomyopathies, but in its early stages comparison between ARVC and RVOT-VT can be challenging and correct diagnosis is crucial.  Right ventricular outflow tract ventricular tachycardia (RVOT-VT) is supposed to be a relatively benign condition whereas ARVC is far from it. Development in the field of imaging is therefore of uppermost interest, this being a diagnostic tool of high importance for cardiologists worldwide.

The research group Integrated Cardiovascular Function headed by Professor Otto Smiseth presented several posters this year. Integrated Cardiovascular Function is part of the center's work package that focuses on waisted work ratio and diastolic heart failure. Prof Smiseth is also the leader of this WP at CCI.
Prof Smiseth is one of the world's leading experts on diastolic function and was recently co-chairing the new official guideline article on diastolic function published by the European Association of Cardiovascular Imaging (EACVI) and American Society of Echocardiography (ASE). He had two presentations about diastolic function during the conference, both were very well attended and Smiseth presented excellent tips on how to implement the new guidelines in clinical practice.

Center PhD fellow Lars Dejgaard in front of his poster. Associate professor Kristina Haugaa during her talk.


Saturday 27th of August


J. Aalen, P. Storsten, E.W. Remme, O. Gjesdal, E. Boe, H. Skulstad, O.A. Smiseth
Load sensitivity in left bundle branch block: septal contribution to left ventricular stroke work is abolished with elevated afterload

Aalen et al have studied how increasing afterload is affecting septal performance in left bundle branch block. This study was done by utilizing a dog model. The results show that septal contribution to left ventricular (LV) stroke work is completely lost with elevated afterload and that the septum instead absorbed energy from work performed in the LV lateral wall.

P. Storsten, J. Aalen, E.W. Remme, O. Gjesdal, E. Boe, O.A. Smiseth, H. Skulstad
Septal motion in left bundle branch block: more wobbling with high afterload.

P. Storsten, E. Boe, E.W. Remme, M. Eriksen, E. Kongsgaard, O. Gjesdal, J. Aalen, O.S. Andersen, O.A. Smiseth, H. Skulstad
Septal beaking in left bundle branch block induces right ventricular dysfunction.

O.S. Andersen, E. Gude, H. Skulstad, K. Broch, A.K. Andreassen, O.A. Smiseth, E.W. Remme
Combining peak mitral inflow and annular velocities with left atrial strain improves estimation of left ventricular filling pressure

L. Gronningsaeter, M.E. Estensen, E. Langesaeter, E. Edvardsen
Cardiorespiratory fitness in women with previous preeclampsia

Chair duty; T. Edvardsen - Cardio-Oncology

Center PhD fellow Petter Storsten in front of his posters.
Read more about the research presented by the research group Integrated
Cardiovascular Function on

Sunday 28th of August


L.G. Klaeboe, I.S. Leren, R.M. Ter Bekke, H. Rosjo, T. Omland, L. Gullestad, K.H. Haugaa, T. Edvardsen
Left ventricular mechanical dispersion predicts outcome in conservatively treated patients with aortic stenosis.

E. Galli, C. Leclercq, M. Fournet, A. Bernard, P. Mabo, E. Samset, A. Hernandez, E. Donal
Interest of a combinatory approach based on traditional LV dyssynchrony parameters and cardiac work estimated by pressure-strain loop curves for the prediction of CRT response.

L.A. Dejgaard, T.F. Haland, O.H. Lie, M. Ribe, I.S. Leren, T. Edvardsen, K.H. Haugaa
Influence of lifetime exposure to physical exercise on ventricular arrhythmias in patients with hypertrophic cardiomyopathy

M. Rodriguez-Lopez, S.I. Sarvari, A. Sepulveda-Martinez, M. Sitges, E. Gratacos, B. Bijnens, F. Crispi
Fetal growth restriction is associated with cardiac remodeling at preadolescent age


O.A. Smiseth  -  Cardiac and non-cardiac causes of suspected HFpEF

O.A. Smiseth  -  How should key data be measured and integrated: E/e’, left atrial volume, PA pressure

Chair duty
; K.H. Haugaa - Prediction of Sudden Death; Do we have a crystal ball?


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Dr. Sarvari, MD, PhD and center
PhD fellow John Aalen during the
Professor Thor Edvardsen during his talk.

Monday 29th of August


O.S. Andersen, E.W. Gude, H. Skulstad, K. Broch, A.K. Andreassen, O.A. Smiseth, E.W. Remme
Peak left atrial strain is determined by left ventricular systolic function and filling pressure
Oral poster

S.I. Sarvari, M. Rodriguez-Lopez, M. Sitges, E. Gratacos, B. Bijnens, F. Crispi
Strain echocardiography demonstrates alterations in left ventricular deformation in preadolescents with previous fetal growth restriction

Fetal growth restriction (FGR) affects about 5 to 10% of newborns and is associated with increased cardiovascular mortality in adulthood. FGR might induce primary cardiac alterations, explaining susceptibility for cardiovascular disease later in life. Within a cohort of fetuses with FGR identified in fetal life and followed-up into preadolescence, echocardiography was performed in 58 preadolescents with FGR (defined as birthweight below 10th centile and 94 preadolescents with normal birthweight gentile.

Global longitudinal strain was significantly decreased while global circumferential strain and global radial strain were increased in FGR as compared to controls. Ejection fraction and cardiac index were similar.

The results suggest that primary cardiac alterations are present in preadolescence with previous FGR. Although, longitudinal LV function was reduced, global LV function was preserved due to increase in circumferential and radial deformation. Nevertheless, these subclinical alterations may explain the increased predisposition to cardiovascular disease in adulthood.

T. Haland
, N.E. Hasselberg, V.M. Almaas, J. Saberniak, I.S. Leren, K.E. Berge, K.H. Haugaa, T. Edvardsen
The systolic paradox in hypertrophic cardiomyopathy, normal ejection fraction and decreased longitudinal function

Ejection fraction (EF) is the fraction representing the amount of blood pumped out of the heart with each heartbeat. EF is the most used parameter for measuring systolic function. Patients with hypertrophic cardiomyopathy (HCM) typically have normal EF, despite a decreased longitudinal function measured by strain echocardiography. This apparently paradox can be explained by smaller cardiac volumes in HCM patients, according to PhD fellow Trine Håland at the Center for Cardiological Innovation.


T. Edvardsen  - Heart failure with preserved ejection fraction - Clinical Case


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Center study nurse, Margareth Ribe together with Edvardsen,
Haugaa and Dejgaard.

Tuesday 30th of August


E. Boe, E.W. Remme, P. Storsten, M. Eriksen, O. Andersen, J. Aalen, E. Kongsgaard, O.A. Smiseth, H. Skulstad
Cardiac resynchronisation therapy improves systolic function during left bund branch block by an upward shift of the end-systolic pressure-volume relation.

E. Galli, C. Leclercq, M. Fournet, A. Bernard, P. Mabo, E. Samset, A. Fernandez, E. Donal
The evaluation of cardiac performance by pressure-strain loops: a useful tool for the identification of responders to cardiac resynchronization therapy
Awarded with Best poster award


K.H. Haugaa - Imaging of ARVC

Center for Cardiological Innovation